A study of more than 229,000 obese adults without diabetes in the United States has shown that weight loss drugs are associated with a decreased risk of obesity-related cancers. The research found that GLP-1 receptor agonists (GLP-1 RAs), such as semaglutide (brand names: Ozempic, Wegovy) and tirzepatide (brand names: Mounjaro and Zepbound), were associated with a 41% decrease in the overall risk of developing cancer among non-diabetic patients who used the drugs for weight management, compared to those who relied on diet and exercise alone.

Chimeric antigen receptor T-cell therapy, or CAR-T, has transformed treatment for blood cancers. The immunotherapy involves reprogramming a patient’s own immune cells to recognize and attack tumor cells. It offers many patients long-lasting remission and even a cure. Yet the approach still fails in many lymphomas—cancers that affect the lymphatic system—especially when cancer cells are located in lymph nodes.

Tracking the brain’s blood flow during neurosurgery represents one of the most critical and challenging parts of the operation. A brief interruption can mean the difference between permanent damage and full recovery, but it’s difficult to track blood flow across the surgical field.

The first human clinical trial of a universal Sarbeco coronavirus vaccine, developed by the University of Cambridge and spin-out DIOSynVax (DVX) Ltd, has shown that the vaccine is safe and has no significant side effects.

Excessive bite force does not cause alveolar bone loss but significantly worsens it when combined with periodontitis, report researchers in a new study. While traumatic occlusion has long been suspected to exacerbate periodontitis, the molecular mechanisms behind this link were poorly understood. Now, using mouse models of both conditions separately and combined, the researchers conducted comprehensive gene expression analysis across multiple periodontal tissues, identifying key inflammatory pathways upregulated in bone when both conditions were present.